Marília Mendonça todos os cantos
Marília Dias Mendonça – Todos os cantos.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>lass=”yoast-text-mark” />>O último show realizado por Marília Mendonça antes de seu falecimento ocorreu em 1º de novembro de 2021, quando a cantora se apresentou na Lucky-Friends Arena, em Sorocaba, para mais de 15 mil pessoas, essa seria a volta aos palcos depois de um longo período de isolamento devido à pandemia.

Durante o show, a artista convidou Valentina, uma menina de 9 anos que enfrenta a Síndrome de Down, para cantar com ela no palco. Depois desse show, a cantora iria fazer várias outras apresentações pelo país, além de gravar várias músicas com outros artistas.
Últimos momentos de Marília.
No dia 5 de novembro de 2021, Mendonça embarcou em um táxi aéreo, em Goiânia, no entanto não chegou no s
/><br />O avião que transportava a cantora, um bimotor Beech Aircraft fabricado em 1984, que segundo a ANAC estava em situação regular e possuía autorização para realizar serviço de táxi aéreo,
Dentro da aeronave, Marília tirava várias fotos e se comunicava com seus fãs.
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<br />A aeronave que levava a cantora, infelizmente caiu na zona rural de Piedade de Caratinga, cidade vizinha a Caratinga, após atingir um cabo de uma torre de distribuição de energia da CEMIG, a poucos quilômetros do aeroporto de Caratinga, onde fa
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Sua morte causou um grande impacto em rede nacional e internacional e vários artistas lamentaram a tragédia e prestaram suas homenagens como Maiara e Maraisa, Henrique e Juliano, Ivete Sangalo, Dulce María, Roberta Miranda (que foi internada
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O velório iniciou-se no Goiânia Arena às 12h30, inicialmente restrito aos familiares e amigos próximos da cantora. Às 13h, o velório foi aberto ao público, prevendo que mais de cem mil pessoas passariam pelo ginásio. O cortejo fúnebre iniciou-se às 17h30, sendo sepultada no Cemitério Memorial Parque de Goiânia.
Essa foi apenas uma das tantas histórias que envolvem essas fotos. Se você conhece outra história que faz parte dessas imagens, deixe aqui nos comentários.
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The following information is intended only as a general overview
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Before starting any new supplement—especially one that
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registered dietitian).
2. Verify the product’s safety and quality through reputable third‑party
testing.
3. Check local regulations; in many jurisdictions, products marketed
as “hormone boosters” may be regulated differently
or even prohibited.
—
## 1. Target Audience & Why They Might Consider
It
| **Audience Segment** | **Primary Motivations / Pain Points** | **How the
Product’s Claims Appeal** |
|———————-|—————————————-|————————————|
| **Men experiencing early signs of age‑related decline** (e.g., reduced libido,
energy, muscle mass) | Concern about “midlife crisis” symptoms; desire to
maintain vitality. | Promises restoration of youthful testosterone
levels, improved sex drive, and better athletic performance.
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| **Bodybuilders / Powerlifters** | Need rapid recovery and higher strength output without steroids.
| Highlights “enhanced protein synthesis,” “faster muscle repair,” and “increased endurance.” |
| **Post‑menopausal women** (though the product
is marketed for men) | Seeking hormonal balance, improved mood, bone density.
| Claims to support overall well‑being and prevent osteoporosis through testosterone analogues that also affect estrogen pathways.
|
| **Health‑conscious consumers** | Concerned with natural supplements rather than pharmaceuticals.
| Positions itself as a “clean” alternative—no prescription needed, free from side effects like hair loss or acne.
|
The marketing strategy thus attempts to broaden the product’s
appeal by positioning it as a general “performance booster” that can benefit various demographic
groups and use cases.
—
## 3. Legal Analysis – Potential Violations
| **Issue** | **Relevant Statute / Regulation** | **Application to Text** | **Likelihood of Violation** |
|———–|———————————–|————————–|—————————–|
| 1. Misleading claims about safety and lack of side effects | **Federal Food, Drug, and Cosmetic
Act (FDCA)** – § 301(b)(2) prohibits false or misleading statements in labeling that could influence consumer decisions.
| Text asserts “no side effects” and “safe for anyone.” No clinical data provided to support these claims.
| High – FDCA applies to any product marketed as
a drug, including supplements that make therapeutic claims.
|
| 2. Unsubstantiated health benefit claims (immunity) | **FDCA** § 301(a)(1): Claims of disease prevention or treatment must be supported by substantial evidence.
| Claim “boosts immunity” and “protects against infections.” No evidence cited.
| High – such claims are therapeutic; must be substantiated.
|
| 3. Misleading “free from” claim (no allergens) | **FDCA** § 301(a)(1):
Statements about absence of substances must be truthful.
| Claims “free from gluten, dairy, soy.” No proof provided.
| Medium – could be false if product contains trace amounts; potential liability for misleading
claims. |
| 4. Possible violation of FDA’s Food Labeling Regulations (nutrition facts).
| **FDA** Nutrition Labeling and Education Act:
requires specific nutrient content on nutrition label.
| If product fails to meet required serving size, ingredient list, or
nutrition claims may be non-compliant. | High – labeling
errors can lead to recalls or enforcement actions. |
| 5. Potential conflict with FDA’s Health Claims Regulations if
claiming disease risk reduction. | **FDA** Regulations (21 CFR Part 101): requires pre-market
approval for health claims. | If product states it reduces
risk of heart disease, need evidence and approval.
| High – mislabeling can result in enforcement
action. |
This table outlines five regulatory issues:
potential misclassification or mislabeling of the product, non‑compliance with labeling requirements (serving
size, ingredient list), possible unauthorized health claims,
lack of pre‑market clearance for certain claims, and inadequate disclosure of relevant information.
—
### 3. Regulatory Guidance / Recommendations
| Issue | Practical Guidance |
|——-|——————–|
| **1. Classification/Regulatory Scope** | • Determine whether the product is a *food*, *dietary supplement*,
or *drugs*.
• If it contains any ingredient that qualifies as a drug (e.g.,
a specific medicinal herb, active compound), classify accordingly and consider applying for FDA approval or IND.
• For food/supplements: comply with GRAS/DSHEA.
|
| **2. Ingredient Safety & GRAS Status** | • Verify each
component’s GRAS status under 21 CFR 117.3 (food) or 21
CFR 190.1 (dietary supplements).
• If any ingredient is not GRAS, either submit a GRAS notification or avoid using it.
• Provide safety data: toxicology studies, human consumption levels.
|
| **3. Labeling Claims** | • Determine permissible
claims per DSHEA: structure–function claims allowed; disease‑treatment
claims prohibited unless FDA approved.
• Ensure that any health benefit statements are substantiated by credible scientific evidence and comply with 21 CFR Part 101 (food labeling).
• Include required disclaimer (“These statements have not been evaluated by the FDA”) if structure–function claim.
|
| **4. Packaging & Storage** | • Specify storage conditions (temperature, humidity) in line with shelf‑life requirements.
• Use materials that preserve product integrity;
comply with 21 CFR Part 104 for food contact substances.
|
| **5. Testing and Quality Control** | • Perform microbiological testing (total viable count, coliforms) and chemical analysis
(active ingredient concentration).
• Ensure GMP compliance and record-keeping per FDA guidance on cosmetics/food supplements.
• Document batch-to-batch consistency; include release criteria in specifications.
|
—
## 4. Risk Assessment & Mitigation
| **Risk** | **Likelihood** | **Impact** | **Mitigation Measures** |
|———-|—————-|————|————————-|
| **Microbial contamination** (e.g., *Salmonella*, *Listeria*) | Medium | High | GMP environment, validated cleaning procedures, HACCP plan,
regular microbiological testing. |
| **Chemical instability or degradation of active ingredients** | Low | Medium | Use antioxidant
packaging, control storage conditions (temperature,
humidity), conduct stability studies. |
| **Allergic reactions to plant extracts** | Low | High | Provide ingredient list on label,
advise consumers with known allergies, consider allergen labeling if applicable.
|
| **Incorrect dosage or overconsumption** | Low | Medium | Clear dosing instructions, warnings against exceeding
recommended dose, child-resistant packaging. |
| **Product contamination during transport/storage** | Medium | Medium |
Temperature-controlled shipping, sealed containers, proper storage guidelines for distributors.
|
—
## 4. Key Points to Communicate in the Product Description
1. **Targeted Relief:** Emphasize that the formulation is specifically designed for
men seeking relief from symptoms of prostatitis and benign prostatic hyperplasia
(BPH).
2. **Evidence‑Based Ingredients:** Highlight the inclusion of *Urtica dioica* root, *Cynara scolymus* extract, and *Quercus robur* bark – all supported by clinical studies
for prostate health.
3. **Safety & Quality:** Mention that the product is manufactured under GMP, uses pharmaceutical‑grade isolates, and
has undergone stability testing (≥24 months shelf life).
4. **Convenience:** State the dosage form (capsules/tablets) with a recommended daily dose of 2–3 units, designed to fit into any routine without complex regimens.
5. **Regulatory Compliance:** Clarify that the product is marketed as a dietary
supplement compliant with FDA/EFSA guidelines for health claims.
These points will resonate with potential customers while
satisfying regulatory scrutiny.
—
## 4. Detailed Production Process (Schematic Flow)
Below is a step‑written by Valley‑step flowchart
of the entire manufacturing cycle, from raw‑material receipt to finished product packaging.
Each stage includes critical control points
and quality checkpoints.
| Stage | Sub‑Process | Key Inputs | Critical Control Points | QC / Testing
|
|——-|————-|————|————————–|————–|
| **1. Raw Material Reception** | – Inspection of incoming batches
– Verification of certificates of analysis (CoA)
| – Pomegranate peel powder
– Pomegranate peel extract
– Sodium bicarbonate | – Visual inspection for discoloration, mold.
– Confirm purity and absence of contaminants. | – Weight measurement
– Moisture content test |
| **2. Drying / Dehumidification** | – Controlled drying (if needed)
– Storage in low‑humidity environment | – Pomegranate peel powder | – Temperature < 40 °C to avoid degradation.
– Relative humidity < 30%. | – Final moisture content measurement |
| **3. Milling / Homogenization** | – Mill powder to fine consistency
– Optional blending with extract | – Powder mixture | – Particle size distribution within target range (< 50 µm). | – Particle size analysis |
| **4. Formulation of the 0.5 g Dose** | – Accurate weighing (±0.001 g tolerance)
– Encapsulation in a suitable capsule or tablet form | – 0.5 g dose | – Use calibrated scales.
– Verify content uniformity across multiple units. | – Batch quality control: weigh several capsules to confirm average weight and variance < 1%. |
| **5. Storage & Handling** | – Store under controlled temperature (20–25 °C) and humidity (≤ 60 % RH).
– Keep away from light if sensitive.
– Label with manufacturing date, expiry date, batch number. | – Follow GMP guidelines. | – Monitor environmental conditions regularly. |
—
### Practical Tips for Accurate Weighing
1. **Use a calibrated analytical balance** that can read at least 0.01 g (10 mg).
2. **Zero the balance with an empty container** before placing the sample to avoid container mass interference.
3. **Avoid drafts or temperature fluctuations**; use a draft shield if possible.
4. **Perform multiple weighings** and average the result for greater accuracy.
5. **Keep the laboratory environment stable** (e.g., no heavy foot traffic, minimal HVAC cycling).
—
### Summary
– The mass of the sample in a 100 mL vial is simply its weight; the volume of the vial does not directly affect it.
– A vial’s density can be computed if you know the total mass and its volume (including material).
– To determine an empty vial’s density, subtract the sample’s mass from the total, then divide by the vial’s volume.
Feel free to ask for clarification on any step or calculation!
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